In pathological states, failing hepatocyte regeneration drives disease progression, while other cells types change liver architecture
Normal hepatocyte regeneration & liver restoration
The liver is continually working to naturally regenerate itself in response to injury from diet, lifestyle or viral infection.
Host Immune Response
In a normally functioning liver, initial hepatocyte injury initiates an immune response, clearing damaged or dead cells.
Hepatocyte regeneration and restore liver function
Pathologic hepatocyte regeneration & changing liver architecture
Broader Immune Response
If the injury persists, the sustained inflammation results in a broader, more aggressive immune response, diminishing hepatocyte regenerative capacity
Activation of myofibroblasts
Activated myofibroblasts depost extracellular matrix (ECM), including collagen, leading to progressive fibrosis.
Excessive ECM abnormal stiffness
Excessive ECM changes the liver’s architecture leading to abnormal stiffness, restricting the ability of hepatocytes to regenerate.
Fibrosis & cirrhosis